AGROBIOLOGIA
Volume 12, Numéro 1, Pages 2810-2818
2022-05-09

Effect Of Administration Of Ginseng Solution Panax Ginseng On Blood Coagulation Parameters Among A Population Of Mice (mus Musculus)



Authors : Aissiou Mohammed Yehya El Amin . Berhoun Celina . Benfardjellah Amira Ghizlaine . Bekka Selma .

Abstract

The current study aims to investigate the anticoagulant potential of Panax ginseng in vitro. We assessed and compared variations in platelet levels, prothrombin time, and activated partial thromboplastic time in 68 Mus Musculus mice divided into three groups: 23 mice fed with 5 percent Panax notoginseng (450mg/kg), 22 mice force-fed with distilled water, and 23 mice force-fed with rice flour (450mg/kg). Our results showed a significant prolongation of the activated partial thromboplastin time following prolonged force-feeding with Panax ginseng solution: AtT0 13. ± 6 sec vs 22.6 ± 1.5sec (Zwilcoxon = -4.19 / P <0.01) at the end of the force-feeding period . The active prothrombin time was 12.5 sec at the beginning of the experiment and 20.45 sec after 45 days of ginseng gavage (Zwilcoxon = -4.27 / P 0.01). Furthermore, the platelet count did not differ significantly across all groups or over the course of the experiment (Z wilkoxon = -4.14 / P = 0.11). This study concludes that panax ginseng has a strong anticoagulant potential. Further research into the antiplatelet potential of panax ginseng should be conducted using other biological indicators, specifically the effect of ginseng on platelet functions.

Keywords

Ginseng ; Blood coagulation ; Mice ; Anticoagulant Proprieties ; antiplatelet agent

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