PhytoChem & BioSub Journal
Volume 10, Numéro 3, Pages 103-120

A New Microwave-assisted Hydrolysis, A Catalytic Acylation And An Efficient Synthesis Of Derivatives Of Flavanones With Hydroxylamine And Phenylhydrazines

Authors : Fandougouma Omar . Belboukhari Nasser . Cheikh Naoual . Villemin Didier . Cheriti Abdelkrim .

Abstract

For the first time, acidic hydrolysis of flavanone-7-O-glycosides was demonstrated under Microwave irradiation. This new economical procedure allowed us to obtain the flavanones in very good yields 90% better than of hydrolysis in reflux. Secondly, we describe for the first time, a profitable synthesis of Hesperidin-octa-acetate, Naringinocta- acetate, Hesperetin-triacetate and Naringenin-triacetate from the flavanones with 4-(N,N-Dimethylamino)-pyridine. We synthetized a series, of oxime derivatives of 2-phenylchroman-4-one; by coupling hydroxylamine with flavanones. We have also able to synthetized and characterized a new products flavanone-4-one hydrazones by standard analytical methods, according to a new reaction between the flavanones and phenylhydrazines derivatives.

Keywords

Flavanone-7-O-glycosides, Microwave, Oxime, Phenylhydrazines