Journal of Molecular and Pharmaceutical Sciences
Volume 2, Numéro 1, Pages 22-32
2023-12-31
Hypovitaminosis D In Patients With Hashimoto’s Thyroiditis In The Region Of Constantine.
Authors : Bechia Camelia Yasmine . Boulkamh Yousra . Bensalem Sihem . Laidouni Imene . Haddad Souad .
Abstract
Abstract. Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune disease. Recently, several works demonstrated the effective role of vitamin D on immunity and the incidence of autoimmune diseases. We conducted a cross-sectional observational study. Its main objective was analyzing the relationship between hypovitaminosis D and autoimmune HT. Our study was carried out at the biochemistry and immunology laboratories of the regional university hospital of Constantine, for a period of 2 months. The study group consisted of 45 HT patients. After data was collected, serum concentrations of vitamin D (25(OH) D), TSH, anti-TPO and anti-Tg auto-antibodies were assessed. Our results indicated that the majority of HT patients were woman. The mean age of the patients was 43.22 ± 11.24 years. In the group 53% of patients had hypothyroidism and 16% of them had type 2 diabetes. Hypovitaminosis D with levels below 30 ng/ml was recorded in 80% of the patients. It was more marked in females than in males (13.98 ± 14.07 ng/ml and 23.20 ± 9.96 ng/ml respectively). Vitamin D levels varied between the different stages of the pathology. In the group, 31.11% had a severe deficiency, 24.44% had a deficiency, and likewise, 24.44% of patients had an insufficiency. A possible association between hypovitaminosis D and HT was highlighted in this study. However, these findings do not confirm the existence of a causal relationship. Further investigations and prospective trials are desirable to characterize this relationship.
Keywords
Hashimoto's thyroiditis ; hypovitaminosis D ; autoimmunity ; 25-OH-D
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