Algerian Journal of Pharmaceutical Engineering
Volume 0, Numéro 0, Pages 5-10
2023-03-30
Effect Of Sodium Alginate-gelatin System On The Dissolution Behavior Of Diclofenac Sodium Microparticles
Authors : Bouchal Fatiha . Ayachi Nabila . Benmeziane Rosa . Lahlou Soraya .
Abstract
gelatin). Methods DFS microparticles were prepared by complex coacervation technique. DFS microparticles were formulated by using different drug and polymers ratios (drug/polymers = 1:1; 1:2 and 1:5 and alginate/gelatin = 1:2; 1:3 and 1:4). Nine (09) essays F1, F2, F3, F4, F5, F6, F7, F8 & F9 of varying concentrations of drug, sodium alginate and gelatin were prepared. DFS microparticles were examined for in-vitro dissolution at pH 6.8 and pH 1.2 to make out the effect of biopolymeric system on the in-vitro drug release. Further, DFS microparticles were characterized by Fourrier Transform Infrared spectroscopy (FTIR). The surface morphology was done by microscopic observation. For each formulation, the production yield was calculated. Results the in-vitro release study indicates that microparticles formulated with 1:2 drug/polymers ratio and 1:3 alginate/gelatin ratio (F5) has shown prolonged drug release in phosphate buffered medium (pH6,8). Conclusion: microparticles loaded with DFS prepared by complex coacervation with sodium alginate-gelatin system could be used for sustained delivery of DFS.
Keywords
Diclofenac sodium. Sodium alginate. Gelatin. Microparticles. in-vitro dissolution.
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