Algerian Journal of Engineering Research
Volume 2, Numéro 3, Pages 19-26
2018-06-01
Comparative Evaluation Of Super Disintegrants And Binder With Formulation Development Of Orodispersible Tablets
Authors : Yamina Haciane . Ouarda Benaziz . Naima Laoufi .
Abstract
The objective of this work is to find a quantitative and qualitative formula for a rapidly disintegrating matrix. For a first approach, fast disintegration matrices were formulated without active ingredient, selecting the quantity, the quality and the mode of introducing the Superdisintegrants and binder on a case-by-case basis. An optimal rapid disintegration matrix was chosen into which an active ingredient was introduced with a disintegration time of 16 s, a Hardness of 4.95 Kp and a friability of 0.45%.
Keywords
Rapidly disintegrating matrix; Tablet orodispersible; Placebo; Wetting time.
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