Algerian Journal of Engineering Research
Volume 2, Numéro 3, Pages 09-12
2018-06-01

Formulation, Characterization And Efficiency Evaluation Of A Hydrogel Formulated With Algerian Thermal Water



Authors : Romaissaa Mokdad . Abdelkader Hadjsadok . Ali Aouabed .

Abstract

Guergour thermal water (GTW) is commonly used in the east of Algeria for treating atopic dermatitis (AD) and psoriasis. Previous works demonstrated its chemical composition rich in minerals and heavy metals. The aims of the present study were (a) to possibly formulate a Hydrogel with GTW as an active agent (b) study the rheological properties and the stability of this Hydrogel (c) study the clinical efficiency of this Hydrogel towards atopic dermatitis symptoms. First, several excipients with both inert physiochemical properties and ability to endure the high salinity of the thermal water were chosen. Second, a Hydrogel was formulated with the thermal water as the major component, carrying out rheological properties and stability studies. The Hydrogel was then tested on patients having AD problems during two weeks. For that, a comparative study was conducted with a Hydrogel with the same formula, but prepared with purified water as vehicle. The evolution of AD symptoms and signs were evaluated based on questionnaires for different considered patients. The GTW being a thermal mineral water emerged with a neutral pH and a highly saline calcium sulfate. The Hydrogel formulated with GTW presented satisfactory rheological and sensory characteristics and was stable for 8 months under specific storage conditions. The clinical results revealed that 65% of AD patients showed significant improvements after the treatment, with partial sore disappearances. This study provided the possibility to use the GTW as an active agent in a stable Hydrogel with therapeutic dermal effect. GTW-Hydrogel applied directly to the skin can be a key issue for AD patient caregivers.

Keywords

Atopic Dermatitis; Guergour Thermal Water; Hydrogel; Rheology; Viscosity

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