REVUE ALGERIENNE D’ALLERGOLOGIE
Volume 3, Numéro 1, Pages 57-61
2018-12-14

A Rare Association Of Thymoma And Immunodeficiency:two Case Reports

Auteurs : Belaid Brahim . Messaoudani Nesrine . Asselah Fatima . Nekhla Ahmed . Boubrit Mustapha . Zidouni Nouredine . Djidjik Réda .

Résumé

In 1954 Robert Good described three patients with thymoma and hypogammaglobulinemia. Today, the condition is designated as Good syndrome [1]. It is typically anadult-onset immunodeficiency rendering patient susceptible to bacterial,opportunisticviral and fungal infections.Hematological disorders and associated autoimmune diseases are also common. Additional immunologic defects in GS may include altered T-cell function with low CD4 cells, and an inverted ratio of CD4 to CD8 cells. The humoral and cellular immunodeficiency in GS is responsible for recurrent respiratory, gastrointestinaland urinary infections from common pathogens [2].The pathogenesis remains unknown and, what is more, no genetic studies have been reported [3,4]. Optimal therapy often requires perioperative medical immunomodulation and surgical resection. Herein, we describe twocases of thymoma with hypogammaglobulinemia and their clinical and immunological presentation.

Mots clés

immunodeficiency; thymoma;Good syndrome

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