JOURNAL ALGÉRIEN DE PHARMACIE
Volume 1, Numéro 1, Pages 29-35

Nasal Carriage Of Staphylococcus Aureus In Healthy Blood Donors: Demographic Profile, Risk Factors And Antimicrobial Susceptibility Testing In The Wilaya Of Tizi-ouzou, Algeria.

Authors : Djerboua Toufik .

Abstract

BACKGROUND: nasal carriage of Staphylococcus aureus is central in the epidemiology and pathogenesis of staphylococcal infections, nevertheless, very few publications are made on this subject especially in the community setting and on healthy people in Algeria. OBJECTIVES: This study aims to put light on the status of healthy people towards S.aureus carriage and the circumstances around it, also we aim to determine the antimicrobial susceptibility profile of the isolated stains METHOD: nasal swabbing was performs of healthy blood donors at Nedir Mohammed blood transfusion unit. Samples were enriched on Brain heart broth then isolated on Chapman plate. Identification was based on Mannitol fermentation and Coagulase test. Antimicrobial susceptibility testing (AST) was performed according to Algerian antimicrobial resistance network recommendations inspired from both CLSI and EUCAST AST guidelines. RESULTS: a total 93 healthy blood donors accepted to participate, mainly men (N=77), the mean age was of 29 years old. Most of them had an occupation (91.43) and reported having one or more risk factors for S.aureus nasal carriage.35 of the participants were carriers of S.aureus mainly men (85.71). 19 of these isolates (54%) were MRSA. Our strains whether MRSA or MSSA showed few resistance to other antibiotics. CONCLUSION: our results show that Staphylococcus aureus nasal carriage is widely distributed among healthy people and MRSA might be more spread than expected. Further studies including the determination of molecular resistance markers on a larger recruitment should allow a more precise determination of the rates of nasal carriage in healthy people and the impact on Staphylococcal infection epidemiology in our region.

Keywords

Staphylococcus Aureus, Nasal Carriage, Risk Factors