Systèmes Agraires et Environnement
Volume 2, Numéro 2, Pages 34-38
2018-07-23
Antimicrobial Evaluation Of New Substituted Hantzsch Thiazole Derivatives
Authors : Bouherrou Houari . Rachedi Yahia . Abderrahmani Ahmed . Abdellaziz Lamia . Dumas Françoise .
Abstract
New thiazole derivatives were synthesized and tested as antimicrobial agents. Synthesized compounds were assayed in vitro for their antimicrobial activity against a panel of selected Gram positive and Gram negative bacteria such as Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa by the disc diffusion and the serial dilution methods. Most of the thiazoles exhibited significant antibacterial activity compared to amoxicillin and ciprofloxacin as positive controls. The entire synthesized compounds and standard antibiotics have effective antibacterial properties against bacteria strains and are most active against Gram negative bacteria than the Gram positive one.
Keywords
Thiazoles; Antibacterial activity; Gram positive bacteria; Gram negative bacteria.
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