Algerian Journal of Natural Products
Volume 4, Numéro 1, Pages 226-232
2016-02-01

Evaluation Of Antibacterial Activities Of Novel Aziridinyl Phosphonates



Authors : Keniche Assia . Bellifa Samia . Hassaine Hafida . Slimani Mohammed Zakaria . Kajima Mulengi Joseph .

Abstract

A new series of aziridines was synthesized in our laboratory, which displays potent antibiotic activities. However, a practical synthesis by using the coupling method of this aziridines with either phosphonate or N-phtaloyl acide moiety can be converted into various derivatives. This work describes new results of our ongoing research targeting new derivatives of biological interest. All the compounds were screened for their antibacterial activity, they all showed comparable moderate to good growth inhibitory activity with reference to Tetracyclin and Gentamicin.

Keywords

aziridine, phosphonate, antibacterial activity, amino acide

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