Algerian Journal of Natural Products
Volume 5, Numéro 2, Pages 463-468
2017-04-13

Antibacterial Activities Of New Compounds Nitrogen Heterocyclic Saturated



Authors : Lefrada Leila . Köhn Randolf D. . Malki Souhila . Mazouz Wissam . Bouchemma Ahcene . Hadjem Meriem .

Abstract

This work describes the synthesis, spectroscopic, structural characterizationandantibacterial activitiesofnew saturated heterocyclic nitrogen compounds of the 1, 3, 5-triazacyclohexanetype.The new triazacyclohexanes(R3TAC)with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:1 mixture of 4-iodoaniline and 2-ethyl1-hexyl aminewithformalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMRand13C NMRand shown to be mainly a mixture of the two mixed triazacylcohexane.These compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.

Keywords

synthesis; triazacyclohexanes; antibacteria

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