Nutrition & Santé
Volume 3, Numéro 1, Pages 40-50

Olea Europaea Leave Extracts And Allopurinol Alleviate Oxidative Stress In Liver Rats Induced By Oxonate

Authors : Gdoura Nesrine . Ghorbel Imen . Murat Jean-claude . Chaabouni Khansa . Makni-ayed Fatma . El Feki Abdelfattah .

Abstract

Introduction. Facing the limits of therapeutic chemical drugs, the research development on medicinal plants has been directed towards obtaining herbal medicines. Objective. This development was an essential step in assessing the protection effect of Olea europaea and allopurinol on biochemical and histological changes in the liver of hyperuricemic rats induced by oxonate. Material and Methods. A control group received daily an intraperitonealy injection (i.p.) of 0.9% NaCl for seven days. Another group received i.p. injection of potassium oxonate (300 mg/kg body weight (BW) (potassium oxonate) and either treated by allopurinol (10mg/kg BW (potassium oxonate + allopurinol ) or fresh leaf Olea europaea extract at a dose of 1500 mg /kg BW (potassium oxonate+Olea). Uric acid, aspartate and alanine amino transaminase and alkaline phosphatase, lipid peroxidation, antioxidant activities of catalase, superoxide dismutase and glutathione peroxidase, and liver histology were assayed. Results. Our results showed a reduction of lipid peroxidation, aspartate, alanine transaminase, alkaline phosphatase and histopathological changes in hyperuricemic rats treated with allopurinol or decoction of olive leaves. Conclusion. There is a more pronounced improvement in rats treated with decoction of Olea europaea than those treated with allopurinol.

Keywords

Hyperuricemic rats, Oxidative stress, Liver, Olea europaea leaves, Allopurinol