Materials & biomaterials science
Volume 3, Numéro 1, Pages 001-009

Synthesis, Characterization And In Vitro Evaluation Of Antibacterial And Antifungal Activities Of New Schiff Base And Its Metal Complexes

Authors : Madani Salim . Mokhnache Kamel . Rouane Azeddine . Charef Noureddine .


A new potentially pentadentate Schiff base ligand L has been prepared via the conden- sation of diethylenetriamine and 2’-hydroxyacetophenone in the molar ratio of 1:2 in absolute ethanol and characterized by elemental analyses and UV, IR spectroscopy. Mn(II), Ni(II), Co(II), Cu(II), Fe(III), Mg(II), Cd(II) and Zn(II) complexes were prepared by reaction of L, dissolved in ethanol, with an appropriate metal salt, have been characterized by UV and IR spectroscopy. Furthermore, the synthesized compounds were screened for antibacterial and antifungal activities. Almost all of these compounds showed moderate to excellent antimicrobial activity against four gram negative bacteria (Escherichia coli, Salmonella typhimurium, Acinetobacter baumannii and Citrobacter freundii), two gram positive bacteria (Enterococcus faecalis and Lysteria monocytogenes), pathogenic fungal strains (Can- dida albicans, Aspergillus niger, Aspergillus flavus and fusarium oxysporum). The activities were confirmed by Activity Index (AI). Activity Index values were found to be higher for Cd(II) followed by Co(II) and the other compounds. The Minimum Inhibitory Concentration (MIC) L and its metal complexes were also determined.


Schiff base, Complexes, Synthesis, Bacteria, Fungus