AGROBIOLOGIA
Volume 9, Numéro 2, Pages 1484-1490
2019-12-30
Evaluation Of Polymorphism Of Icam-1 Gene In A Population On Russian Federation Territory
Authors : Mokrane Ahlem . Perenkov Aleksei Dmitrievitch . Novikov Dmitry Viktopivitch . Fomina Svetlana Grigorivna . Novikov Viktor Vladimirovitch .
Abstract
Description of the subject: Cancer is one of the leading causes of death in the world. Currently, colorectal cancer can be described as a basis for a global problem. It is believed that genetic polymorphism is related to the risk of colorectal cancer development. The intercellular adhesion molecule-1 is shown in several types of cells, such as endothelial cells and leukocytes, and plays an important role in several physiological processes. In addition, this molecule is also expressed in various cancer cells, in particular melanoma, colorectal cancer and lymphoma. Objective: The purpose of this study was to investigate the relationship between the level of ICAM-1 gene expression and genetic polymorphism (rs5498 A/G) in patients with colorectal cancer. Methods: A total of 115 peripheral blood samples of young adults from Nizhny Novgorod were examined. The ICAM-1 mRNA expression was analyzed by real-time PCR. The genotypic distribution of the rs5498 E469K(A/G) gene polymorphism was carried out using a specific polymerase chain reaction allele. Results: The results showed a significant difference between control and colorectal cancer patients for the GG genotype (p=0.002; OR=1.35) and for the G allele (p=0.005; OR=2.20). The present study shows the relationship between SNP rs5498 (A/G) and colorectal cancer with AG genotype (p=0.002; OR=3.55). Conclusion: Our results revealed that polymorphism of rs5498 (E469K) ICAM-1 may be associated with the risk of colorectal cancer.
Keywords
adhesion molecule, cancer cells, Cancer colorectal, cellules cancéreuses, Colorectal cancer, génotypage, genotyping, molécule d'adhésion, polymorphism, polymorphisme
Les articles similaires
Abid Ghania
.
Messal Ahlem
.
Harmel Mohammed
.
Missouri Mohammed
.
Djadaouadji Iness
.
Adda Neggaz Nawel
.
Idder Aicha
.
Abdi Meriem
.
Meroufel Djabaria Naima
.
Fodil Mostafa
.
Zemani-fodil Faouzia
.
pages 41-50.
Labiad Nawal
.
Messatfa Moussa
.
Bouali-youcef Youcef
.
Kadiri Houria
.
Ouikhlef Nardjess
.
pages 45-52.
Abderrahmane Rym
.
Louhibi Lotfi
.
Boubekeur Amina
.
Moghtit Fatima Zohra
.
pages 37-42.
Boubekeur Amina Mama
.
Louhibi Lotfi
.
Mahmoudi Khadidja
.
Moghtit Fatima Zohra
.
pages 57-63.
