Development of a liposomal suspension to increase the skin penetration of Diclofenac

Gherrak, Fouzia; Djilali, Khadija; Hadj Sadok, Abdelkader

Algerian Journal of Engineering Research
Volume 3, Numéro 1, Pages 47-58
2019-06-01

Development Of A Liposomal Suspension To Increase The Skin Penetration Of Diclofenac

Authors : Gherrak Fouzia . Djilali Khadija . Hadj Sadok Abdelkader .

Abstract

The objective of this work was to develop a liposomal suspension encapsulating a non-steroidal anti-inflammatory which will constitute the dispersed phase of a gel for dermic use. Diclofenac preparations for dermal application exist only under the gel and emulgel forms. This liposomal form has been proposed in order to increase the skin penetration or even the availability of Diclofenac due to the phospholipid bilayer of the liposome having the same structure as the skin for cutting the barrier (horny layer). Liposome was formulated from soy lecithin, cholesterol, by the inverse phase evaporation method then optimized and characterized. After then a study of the influence of the excipients used in the basic formulation on certain physicochemical properties (particle size distribution and zeta potential) of the system, was carried out. An experimental design and a response surface methodology were carried out using MODDE 6.0 software. The determined optimum was characterized by a maximum amount of ethanol in relation to water combined with maximum levels of cholesterol and lecithin, promoting the production of small-sized liposomes containing a relatively high surface charge (zeta potential) and having only a narrow polydispersity, thus meeting the stability criteria favoring transposition on an industrial scale.